Native Mass Spectrometry for the Study of PROTAC GNE‐987‐Containing Ternary Complexes

PROteolysis TArgeting Chimeras (PROTACs) promote the degradation, rather than inhibition, of a drug target as a mechanism for therapeutic treatment. Bifunctional PROTAC molecules allow simultaneous binding of both the target protein and an E3‐Ubiquitin ligase, bringing the two proteins into close sp...

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Detalles Bibliográficos
Autores principales: Sternicki, Louise M., Nonomiya, Jim, Liu, Miaomiao, Mulvihill, Melinda M., Quinn, Ronald J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359942/
https://www.ncbi.nlm.nih.gov/pubmed/33792163
http://dx.doi.org/10.1002/cmdc.202100113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359942/
https://www.ncbi.nlm.nih.gov/pubmed/33792163
http://dx.doi.org/10.1002/cmdc.202100113

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