Expanding the Substrate Scope of Nitrating Cytochrome P450 TxtE by Active Site Engineering of a Reductase Fusion

Aromatic nitration reactions are a cornerstone of organic chemistry, but are challenging to scale due to corrosive reagents and elevated temperatures. The cytochrome P450 TxtE nitrates the indole 4‐position of l‐tryptophan at room temperature using NO, O(2) and NADPH, and has potential to be develop...

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Detalles Bibliográficos
Autores principales: Saroay, Rakesh, Roiban, Gheorghe‐Doru, Alkhalaf, Lona M., Challis, Gregory L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359946/
https://www.ncbi.nlm.nih.gov/pubmed/33851500
http://dx.doi.org/10.1002/cbic.202100145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8359946/
https://www.ncbi.nlm.nih.gov/pubmed/33851500
http://dx.doi.org/10.1002/cbic.202100145

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