Successful Prediction of Human Steady‐State Unbound Brain‐to‐Plasma Concentration Ratio of P‐gp Substrates Using the Proteomics‐Informed Relative Expression Factor Approach

In order to optimize central nervous system (CNS) drug development, accurate prediction of the drug’s human steady‐state unbound brain interstitial fluid‐to‐plasma concentration ratio (K(p,uu,brain)) is critical, especially for drugs that are effluxed by the multiple drug resistance transporters (e....

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Detalles Bibliográficos
Autores principales: Storelli, Flavia, Anoshchenko, Olena, Unadkat, Jashvant D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360000/
https://www.ncbi.nlm.nih.gov/pubmed/33675056
http://dx.doi.org/10.1002/cpt.2227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360000/
https://www.ncbi.nlm.nih.gov/pubmed/33675056
http://dx.doi.org/10.1002/cpt.2227

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