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FVIII inhibitors display FV‐neutralizing activity in the prothrombin time assay

BACKGROUND: The coagulation factors (F)V and VIII are homologous proteins that support hemostasis through their regulation of FX activity. Hemophilia A (HA) patients have reduced FVIII activity and a prolonged bleeding time that is corrected through the administration of exogenous FVIII. Around one‐...

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Detalles Bibliográficos
Autores principales: Arsiccio, Andrea, Beavis, James, Raut, Sanj, Coxon, Carmen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360109/
https://www.ncbi.nlm.nih.gov/pubmed/33914406
http://dx.doi.org/10.1111/jth.15355