Antiprotozoal Structure–Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action

Leucinostatin A is one of the most potent antiprotozoal compounds ever described, but little was known on structure–activity relationships (SAR). We used Trypanosoma brucei as a protozoal model organism to test synthetically modified derivatives, resulting in simplified but equally active compounds...

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Detalles Bibliográficos
Autores principales: Brand, Michael, Wang, Lei, Agnello, Stefano, Gazzola, Silvia, Gall, Flavio M., Raguž, Luka, Kaiser, Marcel, Schmidt, Remo S., Ritschl, Amélie, Jelk, Jennifer, Hemphill, Andrew, Mäser, Pascal, Bütikofer, Peter, Adams, Michael, Riedl, Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360131/
https://www.ncbi.nlm.nih.gov/pubmed/33730410
http://dx.doi.org/10.1002/anie.202102153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360131/
https://www.ncbi.nlm.nih.gov/pubmed/33730410
http://dx.doi.org/10.1002/anie.202102153

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