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Design and Synthesis of Simplified Polyketide Analogs: New Modalities beyond the Rule of 5
Natural products provide important lead structures for development of pharmaceutical agents or present attractive tools for medicinal chemistry. However, structurally complex and thus less accessible metabolites defying conventional drug‐like properties, as expressed by Pfizer's rule of five, h...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley and Sons Inc.
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360190/ https://www.ncbi.nlm.nih.gov/pubmed/33755304 http://dx.doi.org/10.1002/cmdc.202100150 |