Cargando…

Norcycloartocarpin targets Akt and suppresses Akt-dependent survival and epithelial-mesenchymal transition in lung cancer cells

In searching for novel targeted therapeutic agents for lung cancer treatment, norcycloartocarpin from Artocarpus gomezianus was reported in this study to promisingly interacted with Akt and exerted the apoptosis induction and epithelial-to-mesenchymal transition suppression. Selective cytotoxic prof...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nonpanya, Nongyao, Sanookpan, Kittipong, Joyjamras, Keerati, Wichadakul, Duangdao, Sritularak, Boonchoo, Chaotham, Chatchai, Chanvorachote, Pithi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360371/ https://www.ncbi.nlm.nih.gov/pubmed/34383763 http://dx.doi.org/10.1371/journal.pone.0254929

Ejemplares similares

Ovalitenone Inhibits the Migration of Lung Cancer Cells via the Suppression of AKT/mTOR and Epithelial-to-Mesenchymal Transition
por: Sanookpan, Kittipong, et al.
Publicado: (2021)

Artocarpin Targets Focal Adhesion Kinase-Dependent Epithelial to Mesenchymal Transition and Suppresses Migratory-Associated Integrins in Lung Cancer Cells
por: Nonpanya, Nongyao, et al.
Publicado: (2021)

Response surface optimization of enzymatic hydrolysis and ROS scavenging activity of silk sericin hydrolysates
por: Joyjamras, Keerati, et al.
Publicado: (2022)

Cycloartocarpin Inhibits Migration through the Suppression of Epithelial-to-Mesenchymal Transition and FAK/AKT Signaling in Non-Small-Cell Lung Cancer Cells
por: Tungsukruthai, Sucharat, et al.
Publicado: (2022)

Cypripedin diminishes an epithelial-to-mesenchymal transition in non-small cell lung cancer cells through suppression of Akt/GSK-3β signalling
por: Treesuwan, Surassawadee, et al.
Publicado: (2018)

Recycled Sericin Hydrolysates Modified by Alcalase(®) Suppress Melanogenesis in Human Melanin-Producing Cells via Modulating MITF
por: Joyjamras, Keerati, et al.
Publicado: (2022)

Phoyunnanin E inhibits migration of non-small cell lung cancer cells via suppression of epithelial-to-mesenchymal transition and integrin αv and integrin β3
por: Petpiroon, Nareerat, et al.
Publicado: (2017)

Expression of plant-produced anti-PD-L1 antibody with anoikis sensitizing activity in human lung cancer cells via., suppression on epithelial-mesenchymal transition
por: Phetphoung, Thareeya, et al.
Publicado: (2022)

Correction: Phoyunnanin E inhibits migration of non-small cell lung cancer cells via suppression of epithelial-to-mesenchymal transition and integrin αv and integrin β3
por: Petpiroon, Nareerat, et al.
Publicado: (2023)

Hydroquinone 5-O-Cinnamoyl Ester of Renieramycin M Suppresses Lung Cancer Stem Cells by Targeting Akt and Destabilizes c-Myc
por: Hongwiangchan, Nattamon, et al.
Publicado: (2021)

Suppressing Cdk5 Activity by Luteolin Inhibits MPP(+)-Induced Apoptotic of Neuroblastoma through Erk/Drp1 and Fak/Akt/GSK3β Pathways
por: Reudhabibadh, Ratchaneekorn, et al.
Publicado: (2021)

Gigantol Inhibits Epithelial to Mesenchymal Process in Human Lung Cancer Cells
por: Unahabhokha, Thitita, et al.
Publicado: (2016)

Artonin F Induces the Ubiquitin-Proteasomal Degradation of c-Met and Decreases Akt-mTOR Signaling
por: Soonnarong, Rapeepun, et al.
Publicado: (2022)

Phytochemicals from Vanda bensonii and Their Bioactivities to Inhibit Growth and Metastasis of Non-Small Cell Lung Cancer Cells
por: Jimoh, Tajudeen O., et al.
Publicado: (2022)

Stemness-Suppressive Effect of Bibenzyl from Dendrobium ellipsophyllum in Human Lung Cancer Stem-Like Cells
por: Taweecheep, Pornchanok, et al.
Publicado: (2021)

Three New Dihydrophenanthrene Derivatives from Cymbidium ensifolium and Their Cytotoxicity against Cancer Cells
por: Jimoh, Tajudeen O., et al.
Publicado: (2022)

Pongol Methyl Ether Inhibits Akt and Suppresses Cancer Stem Cell Phenotypes in Lung Cancer Cells
por: Silapech, Arnon, et al.
Publicado: (2021)

Akt/mTOR Targeting Activity of Resveratrol Derivatives in Non-Small Lung Cancer
por: Innets, Bhurichaya, et al.
Publicado: (2022)

Moscatilin Inhibits Lung Cancer Cell Motility and Invasion via Suppression of Endogenous Reactive Oxygen Species
por: Kowitdamrong, Akkarawut, et al.
Publicado: (2013)

Eriodictyol Attenuates H(2)O(2)-Induced Oxidative Damage in Human Dermal Fibroblasts through Enhanced Capacity of Antioxidant Machinery
por: Buranasudja, Visarut, et al.
Publicado: (2022)

Cisplatin-induced hydroxyl radicals mediate pro-survival autophagy in human lung cancer H460 cells
por: Sumkhemthong, Somruethai, et al.
Publicado: (2021)

5-O-(N-Boc-l-Alanine)-Renieramycin T Induces Cancer Stem Cell Apoptosis via Targeting Akt Signaling
por: Suksamai, Darinthip, et al.
Publicado: (2022)

Peptides extracted from edible mushroom: Lentinus squarrosulus induces apoptosis in human lung cancer cells
por: Prateep, Arisara, et al.
Publicado: (2017)

Cytotoxic and Antimigratory Activities of Phenolic Compounds from Dendrobium brymerianum
por: Klongkumnuankarn, Pornprom, et al.
Publicado: (2015)

Triclosan Potentiates Epithelial-To-Mesenchymal Transition in Anoikis-Resistant Human Lung Cancer Cells
por: Winitthana, Thidarat, et al.
Publicado: (2014)

Pharmacological Ascorbate Elicits Anti-Cancer Activities against Non-Small Cell Lung Cancer through Hydrogen-Peroxide-Induced-DNA-Damage
por: Sanookpan, Kittipong, et al.
Publicado: (2023)

Inhibitory Effect of Isopanduratin A on Adipogenesis: A Study of Possible Mechanisms
por: Rungsa, Prapenpuksiri, et al.
Publicado: (2023)

Caveolin-1 induces lamellipodia formation via an Akt-dependent pathway
por: Chanvorachote, Pithi, et al.
Publicado: (2014)

Epithelial-mesenchymal transition mediates anoikis resistance and enhances invasion in pleural effusion-derived human lung cancer cells
por: CHUNHACHA, PREEDAKORN, et al.
Publicado: (2013)

Prolonged Nitric Oxide Exposure Enhances Anoikis Resistance and Migration through Epithelial-Mesenchymal Transition and Caveolin-1 Upregulation
por: Chanvorachote, Pithi, et al.
Publicado: (2014)

Development of a human antibody fragment directed against the alpha folate receptor as a promising molecule for targeted application
por: Parakasikron, Nattihda, et al.
Publicado: (2021)

How do prolonged anchorage-free lifetimes strengthen non-small-cell lung cancer cells to evade anoikis? – A link with altered cellular metabolomics
por: Sungthong, Rungroch, et al.
Publicado: (2023)

Jorunnamycin A Suppresses Stem-Like Phenotypes and Sensitizes Cisplatin-Induced Apoptosis in Cancer Stem-Like Cell-Enriched Spheroids of Human Lung Cancer Cells
por: Sumkhemthong, Somruethai, et al.
Publicado: (2021)

Colicin N Mediates Apoptosis and Suppresses Integrin-Modulated Survival in Human Lung Cancer Cells
por: Arunmanee, Wanatchaporn, et al.
Publicado: (2020)

Avicequinone B sensitizes anoikis in human lung cancer cells
por: Prateep, Arisara, et al.
Publicado: (2018)

Triple-negative breast cancer influences a mixed M1/M2 macrophage phenotype associated with tumor aggressiveness
por: Pe, Kristine Cate S., et al.
Publicado: (2022)

Zinc induces epithelial to mesenchymal transition in human lung cancer H460 cells via superoxide anion-dependent mechanism
por: Ninsontia, Chuanpit, et al.
Publicado: (2016)

Pinostrobin: An Adipogenic Suppressor from Fingerroot (Boesenbergia rotunda) and Its Possible Mechanisms
por: San, Htoo Tint, et al.
Publicado: (2022)

α-Glucosidase Inhibitory Activity and Anti-Adipogenic Effect of Compounds from Dendrobium delacourii
por: Thant, May Thazin, et al.
Publicado: (2022)

Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial–mesenchymal transition
por: Irie, Hanna Y., et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_tj8a8tj500vhkle6hh1k8ctmm6