LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice

Notch signaling primarily determines T-cell fate. However, the molecular mechanisms underlying the maintenance of T-lineage potential in pre-thymic progenitors remain unclear. Here, we established two murine Ebf1-deficient pro-B cell lines, with and without T-lineage potential. The latter expressed...

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Detalles Bibliográficos
Autores principales: Hirano, Ken-ichi, Hosokawa, Hiroyuki, Koizumi, Maria, Endo, Yusuke, Yahata, Takashi, Ando, Kiyoshi, Hozumi, Katsuto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360648/
https://www.ncbi.nlm.nih.gov/pubmed/34382935
http://dx.doi.org/10.7554/eLife.68227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360648/
https://www.ncbi.nlm.nih.gov/pubmed/34382935
http://dx.doi.org/10.7554/eLife.68227

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