Adipocyte NR1D1 dictates adipose tissue expansion during obesity

The circadian clock component NR1D1 (REVERBα) is considered a dominant regulator of lipid metabolism, with global Nr1d1 deletion driving dysregulation of white adipose tissue (WAT) lipogenesis and obesity. However, a similar phenotype is not observed under adipocyte-selective deletion (Nr1d1(Flox2-6...

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Detalles Bibliográficos
Autores principales: Hunter, Ann Louise, Pelekanou, Charlotte E, Barron, Nichola J, Northeast, Rebecca C, Grudzien, Magdalena, Adamson, Antony D, Downton, Polly, Cornfield, Thomas, Cunningham, Peter S, Billaud, Jean-Noel, Hodson, Leanne, Loudon, Andrew SI, Unwin, Richard D, Iqbal, Mudassar, Ray, David W, Bechtold, David A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360653/
https://www.ncbi.nlm.nih.gov/pubmed/34350828
http://dx.doi.org/10.7554/eLife.63324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360653/
https://www.ncbi.nlm.nih.gov/pubmed/34350828
http://dx.doi.org/10.7554/eLife.63324

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