IL-36γ-armed oncolytic virus exerts superior efficacy through induction of potent adaptive antitumor immunity

In this study, we aimed to apply the cytokine IL-36γ to cancer immunotherapy by constructing new oncolytic vaccinia viruses (OV) expressing interleukin-36γ (IL-36γ-OVs), leveraging unique synergism between OV and IL-36γ’s ability to promote antitumor adaptive immunity and modulate tumor microenviron...

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Detalles Bibliográficos
Autores principales: Yang, Min, Giehl, Esther, Feng, Chao, Feist, Mathilde, Chen, Hongqi, Dai, Enyong, Liu, Zuqiang, Ma, Congrong, Ravindranathan, Roshni, Bartlett, David L., Lu, Binfeng, Guo, Zong Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360872/
https://www.ncbi.nlm.nih.gov/pubmed/33538860
http://dx.doi.org/10.1007/s00262-021-02860-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360872/
https://www.ncbi.nlm.nih.gov/pubmed/33538860
http://dx.doi.org/10.1007/s00262-021-02860-4

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