Clearance of peripheral nerve misfolded mutant protein by infiltrated macrophages correlates with motor neuron disease progression

Macrophages expressing C–C chemokine receptor type 2 (CCR2) infiltrate the central and peripheral neural tissues of amyotrophic lateral sclerosis (ALS) patients. To identify the functional role of CCR2(+) macrophages in the pathomechanisms of ALS, we used an ALS animal model, mutant Cu/Zn superoxide...

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Detalles Bibliográficos
Autores principales: Shiraishi, Wataru, Yamasaki, Ryo, Hashimoto, Yu, Ko, Senri, Kobayakawa, Yuko, Isobe, Noriko, Matsushita, Takuya, Kira, Jun-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360983/
https://www.ncbi.nlm.nih.gov/pubmed/34385589
http://dx.doi.org/10.1038/s41598-021-96064-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360983/
https://www.ncbi.nlm.nih.gov/pubmed/34385589
http://dx.doi.org/10.1038/s41598-021-96064-6

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