Expression of a human cDNA in moss results in spliced mRNAs and fragmentary protein isoforms

Production of biopharmaceuticals relies on the expression of mammalian cDNAs in host organisms. Here we show that the expression of a human cDNA in the moss Physcomitrium patens generates the expected full-length and four additional transcripts due to unexpected splicing. This mRNA splicing results...

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Detalles Bibliográficos
Autores principales: Top, Oguz, Milferstaedt, Stella W. L., van Gessel, Nico, Hoernstein, Sebastian N. W., Özdemir, Bugra, Decker, Eva L., Reski, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361020/
https://www.ncbi.nlm.nih.gov/pubmed/34385580
http://dx.doi.org/10.1038/s42003-021-02486-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361020/
https://www.ncbi.nlm.nih.gov/pubmed/34385580
http://dx.doi.org/10.1038/s42003-021-02486-3

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