Patched regulates lipid homeostasis by controlling cellular cholesterol levels

Hedgehog (Hh) signaling is essential during development and in organ physiology. In the canonical pathway, Hh binding to Patched (PTCH) relieves the inhibition of Smoothened (SMO). Yet, PTCH may also perform SMO-independent functions. While the PTCH homolog PTC-3 is essential in C. elegans, worms la...

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Detalles Bibliográficos
Autores principales: Cadena del Castillo, Carla E., Hannich, J. Thomas, Kaech, Andres, Chiyoda, Hirohisa, Brewer, Jonathan, Fukuyama, Masamitsu, Færgeman, Nils J., Riezman, Howard, Spang, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361143/
https://www.ncbi.nlm.nih.gov/pubmed/34385431
http://dx.doi.org/10.1038/s41467-021-24995-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361143/
https://www.ncbi.nlm.nih.gov/pubmed/34385431
http://dx.doi.org/10.1038/s41467-021-24995-9

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