NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice

We recently showed that NOTUM, a liver-secreted Wnt inhibitor, can acutely promote browning of white adipose. We now report studies of chronic overexpression of NOTUM in liver indicating that it protects against diet-induced obesity and improves glucose homeostasis in mice. Adeno-associated virus (A...

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Detalles Bibliográficos
Autores principales: Guo, Fangfei, Seldin, Marcus, Péterfy, Miklós, Charugundla, Sarada, Zhou, Zhiqiang, Lee, Stephen D., Mouton, Alice, Rajbhandari, Prashant, Zhang, Wenchao, Pellegrini, Matteo, Tontonoz, Peter, Lusis, Aldons J., Shih, Diana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361163/
https://www.ncbi.nlm.nih.gov/pubmed/34385484
http://dx.doi.org/10.1038/s41598-021-95720-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361163/
https://www.ncbi.nlm.nih.gov/pubmed/34385484
http://dx.doi.org/10.1038/s41598-021-95720-1

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