Cargando…

Constitutive BAK/MCL1 complexes predict paclitaxel and S63845 sensitivity of ovarian cancer

We previously found that preformed complexes of BAK with antiapoptotic BCL2 proteins predict BH3 mimetic sensitivities in lymphohematopoietic cells. These complexes have not previously been examined in solid tumors or in the context of conventional anticancer drugs. Here we show the relative amount...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Dongyan, Hou, Xiaonan, Wu, Wangyu, Zanfagnin, Valentina, Li, Yunjian, Correia, Cristina, Zhao, Zhiyang, Zhao, Chenggang, Liu, Zhirong, Zhang, Tao, Fang, Zhiyou, Wang, Hongzhi, Xu, Chao, Weroha, Saravut J., Kaufmann, Scott H., Dai, Haiming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361168/ https://www.ncbi.nlm.nih.gov/pubmed/34385422 http://dx.doi.org/10.1038/s41419-021-04073-0

Ejemplares similares

Correction: Constitutive BAK/MCL1 complexes predict paclitaxel and S63845 sensitivity of ovarian cancer
por: Liu, Dongyan, et al.
Publicado: (2021)

Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate
por: Hu, Lei, et al.
Publicado: (2020)

MCL-1 Inhibitor S63845 Distinctively Affects Intramedullary and Extramedullary Hematopoiesis
por: Zhang, Hexiao, et al.
Publicado: (2023)

Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells
por: Dai, Haiming, et al.
Publicado: (2015)

MCL1 inhibitors S63845/MIK665 plus Navitoclax synergistically kill difficult-to-treat melanoma cells
por: Mukherjee, Nabanita, et al.
Publicado: (2020)

Combination of tyrosine kinase inhibitors and the MCL1 inhibitor S63845 exerts synergistic antitumorigenic effects on CML cells
por: Malyukova, Alena, et al.
Publicado: (2021)

Sensitivity of Cutaneous T-Cell Lymphoma Cells to the Mcl-1 Inhibitor S63845 Correlates with the Lack of Bcl-w Expression
por: Sumarni, Uly, et al.
Publicado: (2022)

Eltrombopag directly activates BAK and induces apoptosis
por: Chen, Meng, et al.
Publicado: (2023)

Pharmaceutical Drug Metformin and MCL1 Inhibitor S63845 Exhibit Anticancer Activity in Myeloid Leukemia Cells via Redox Remodeling
por: Valiulienė, Giedrė, et al.
Publicado: (2021)

BMI1-Inhibitor PTC596 in Combination with MCL1 Inhibitor S63845 or MEK Inhibitor Trametinib in the Treatment of Acute Leukemia
por: Seipel, Katja, et al.
Publicado: (2021)

Specific Glioma Prognostic Subtype Distinctions Based on DNA Methylation Patterns
por: Chen, Xueran, et al.
Publicado: (2019)

MCL-1ES Induces MCL-1L-Dependent BAX- and BAK-Independent Mitochondrial Apoptosis
por: Kim, Jae-Hong, et al.
Publicado: (2013)

The MCL1-specific inhibitor S63845 acts synergistically with venetoclax/ABT-199 to induce apoptosis in T-cell acute lymphoblastic leukemia cells
por: Li, Zhaodong, et al.
Publicado: (2018)

Dual intracellular targeting by ruxolitinib and the Mcl-1 inhibitor S63845 in interleukin-6-dependent myeloma cells blocks in vivo tumor growth
por: Burger, Renate, et al.
Publicado: (2021)

Characterization of an alternative BAK-binding site for BH3 peptides
por: Ye, Kaiqin, et al.
Publicado: (2020)

Supervillin promotes tumor angiogenesis in liver cancer
por: Zhao, Chenggang, et al.
Publicado: (2020)

Systematic Profiling of Alternative mRNA Splicing Signature for Predicting Glioblastoma Prognosis
por: Chen, Xueran, et al.
Publicado: (2019)

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization
por: Dai, Haiming, et al.
Publicado: (2011)

Bak Conformational Changes Induced by Ligand Binding: Insight into BH3 Domain Binding and Bak Homo-Oligomerization
por: Pang, Yuan-Ping, et al.
Publicado: (2012)

Bak and Mcl-1 are essential for Temozolomide induced cell death in human glioma
por: Gratas, Catherine, et al.
Publicado: (2014)

DHHC protein family targets different subsets of glioma stem cells in specific niches
por: Chen, Xueran, et al.
Publicado: (2019)

NDRG2 contributes to cisplatin sensitivity through modulation of BAK-to-Mcl-1 ratio
por: Park, Soojong, et al.
Publicado: (2018)

Guanylate-binding proteins induce apoptosis of leukemia cells by regulating MCL-1 and BAK
por: Luo, Yongyang, et al.
Publicado: (2021)

Mcl-1 promotes survival of thymocytes by inhibition of Bak in a pathway separate from Bcl-2
por: Dunkle, Alexis, et al.
Publicado: (2010)

Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1’s inhibitory effect on Bak
por: Wang, Chunxin, et al.
Publicado: (2011)

Sindbis viral vector induced apoptosis requires translational inhibition and signaling through Mcl-1 and Bak
por: Venticinque, Lisa, et al.
Publicado: (2010)

Paclitaxel-Induced Apoptosis Is BAK-Dependent, but BAX and BIM-Independent in Breast Tumor
por: Miller, Anna V., et al.
Publicado: (2013)

Rationale for a Combination Therapy with the STAT5 Inhibitor AC-4-130 and the MCL1 Inhibitor S63845 in the Treatment of FLT3-Mutated or TET2-Mutated Acute Myeloid Leukemia
por: Seipel, Katja, et al.
Publicado: (2021)

Dual targeting of BCL2 and MCL1 rescues myeloma cells resistant to BCL2 and MCL1 inhibitors associated with the formation of BAX/BAK hetero-complexes
por: Seiller, Carolane, et al.
Publicado: (2020)

TRIM22-Mediated Apoptosis is Associated with Bak Oligomerization in Monocytes
por: Chen, Chi, et al.
Publicado: (2017)

Generating real-world evidence from unstructured clinical notes to examine clinical utility of genetic tests: use case in BRCAness
por: Zhao, Yiqing, et al.
Publicado: (2021)

M. leprae inhibits apoptosis in THP-1 cells by downregulation of Bad and Bak and upregulation of Mcl-1 gene expression
por: Hasan, Zahra, et al.
Publicado: (2006)

Up-Regulation of Mcl-1 and Bak by Coronavirus Infection of Human, Avian and Animal Cells Modulates Apoptosis and Viral Replication
por: Zhong, Yanxin, et al.
Publicado: (2012)

Endogenous Bak inhibitors Mcl-1 and Bcl-x(L): differential impact on TRAIL resistance in Bax-deficient carcinoma
por: Gillissen, Bernhard, et al.
Publicado: (2010)

Bak and Bcl-xL Participate in Regulating Sensitivity of Solid Tumor Derived Cell Lines to Mcl-1 Inhibitors
por: Senichkin, Viacheslav V., et al.
Publicado: (2021)

Protein Palmitoylation Regulates Cell Survival by Modulating XBP1 Activity in Glioblastoma Multiforme
por: Chen, Xueran, et al.
Publicado: (2020)

LY2157299 Monohydrate, a TGF-βR1 Inhibitor, Suppresses Tumor Growth and Ascites Development in Ovarian Cancer
por: Zhang, Qing, et al.
Publicado: (2018)

Delayed apoptosis by neutrophils from COPD patients is associated with altered bak, bcl-xl, and mcl-1 mRNA expression
por: Zhang, Jisong, et al.
Publicado: (2012)

Stroma-Mediated Resistance to S63845 and Venetoclax through MCL-1 and BCL-2 Expression Changes Induced by miR-193b-3p and miR-21-5p Dysregulation in Multiple Myeloma
por: Algarín, Esperanza M., et al.
Publicado: (2021)

BAK-up: the receptor kinase BAK-TO-LIFE 2 enhances immunity when BAK1 is lacking
por: Fallahzadeh-Mamaghami, Vahid, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_3i8g67k5chmci8bjjpmfs1gko2