Hedgehog/GLI1 Transcriptionally Regulates FANCD2 in Ovarian Tumor Cells: Its Inhibition Induces HR-Deficiency and Synergistic Lethality with PARP Inhibition.

Ovarian cancer (OC) is one of the most lethal type of cancer in women due to a lack of effective targeted therapies and high rates of treatment resistance and disease recurrence. Recently Poly (ADP-ribose) polymerase inhibitors (PARPi) have shown promise as chemotherapeutic agents; however, their ef...

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Detalles Bibliográficos
Autores principales: Mani, Chinnadurai, Tripathi, Kaushlendra, Chaudhary, Sandeep, Somasagara, Ranganatha R., Rocconi, Rodney P., Crasto, Chiquito, Reedy, Mark, Athar, Mohammad, Palle, Komaraiah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361230/
https://www.ncbi.nlm.nih.gov/pubmed/34380074
http://dx.doi.org/10.1016/j.neo.2021.06.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361230/
https://www.ncbi.nlm.nih.gov/pubmed/34380074
http://dx.doi.org/10.1016/j.neo.2021.06.010

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