Differential effects of short- and long-term treatment with mepolizumab on eosinophil kinetics in blood and sputum in eosinophilic asthma

Mepolizumab (anti-IL-5) is a successful biological for treatment of T2/eosinophilic asthma by blocking the IL-5-eosinophil axis. The kinetics of human eosinophils in blood and sputum was determined to better understand the underlying mechanism(s). Pulse-chase labeling was performed with 6,6-(2)H(2)-...

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Detalles Bibliográficos
Autores principales: Hassani, Marwan, Tak, Tamar, van Aalst, Corneli, van Nederveen, Saar, Tesselaar, Kiki, Vrisekoop, Nienke, Koenderman, Leo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361259/
https://www.ncbi.nlm.nih.gov/pubmed/34409272
http://dx.doi.org/10.1016/j.isci.2021.102913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361259/
https://www.ncbi.nlm.nih.gov/pubmed/34409272
http://dx.doi.org/10.1016/j.isci.2021.102913

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