A general strategy for the synthesis of α-trifluoromethyl- and α-perfluoroalkyl-β-lactams via palladium-catalyzed carbonylation

β-Lactam compounds play a key role in medicinal chemistry, specifically as the most important class of antibiotics. Here, we report a novel one-step approach for the synthesis of α-(trifluoromethyl)-β-lactams and related products from fluorinated olefins, anilines and CO. Utilization of an advanced...

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Detalles Bibliográficos
Autores principales: Li, Yang, Zhang, Cai-Lin, Huang, Wei-Heng, Sun, Ning, Hao, Meng, Neumann, Helfried, Beller, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361786/
https://www.ncbi.nlm.nih.gov/pubmed/34447539
http://dx.doi.org/10.1039/d1sc02212a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361786/
https://www.ncbi.nlm.nih.gov/pubmed/34447539
http://dx.doi.org/10.1039/d1sc02212a

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