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A general strategy for the synthesis of α-trifluoromethyl- and α-perfluoroalkyl-β-lactams via palladium-catalyzed carbonylation
β-Lactam compounds play a key role in medicinal chemistry, specifically as the most important class of antibiotics. Here, we report a novel one-step approach for the synthesis of α-(trifluoromethyl)-β-lactams and related products from fluorinated olefins, anilines and CO. Utilization of an advanced...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361786/ https://www.ncbi.nlm.nih.gov/pubmed/34447539 http://dx.doi.org/10.1039/d1sc02212a |
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author | Li, Yang Zhang, Cai-Lin Huang, Wei-Heng Sun, Ning Hao, Meng Neumann, Helfried Beller, Matthias |
author_facet | Li, Yang Zhang, Cai-Lin Huang, Wei-Heng Sun, Ning Hao, Meng Neumann, Helfried Beller, Matthias |
author_sort | Li, Yang |
collection | PubMed |
description | β-Lactam compounds play a key role in medicinal chemistry, specifically as the most important class of antibiotics. Here, we report a novel one-step approach for the synthesis of α-(trifluoromethyl)-β-lactams and related products from fluorinated olefins, anilines and CO. Utilization of an advanced palladium catalyst system with the Ruphos ligand allows for selective cycloaminocarbonylations to give diverse fluorinated β-lactams in high yields. |
format | Online Article Text |
id | pubmed-8361786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-83617862021-08-25 A general strategy for the synthesis of α-trifluoromethyl- and α-perfluoroalkyl-β-lactams via palladium-catalyzed carbonylation Li, Yang Zhang, Cai-Lin Huang, Wei-Heng Sun, Ning Hao, Meng Neumann, Helfried Beller, Matthias Chem Sci Chemistry β-Lactam compounds play a key role in medicinal chemistry, specifically as the most important class of antibiotics. Here, we report a novel one-step approach for the synthesis of α-(trifluoromethyl)-β-lactams and related products from fluorinated olefins, anilines and CO. Utilization of an advanced palladium catalyst system with the Ruphos ligand allows for selective cycloaminocarbonylations to give diverse fluorinated β-lactams in high yields. The Royal Society of Chemistry 2021-07-12 /pmc/articles/PMC8361786/ /pubmed/34447539 http://dx.doi.org/10.1039/d1sc02212a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Li, Yang Zhang, Cai-Lin Huang, Wei-Heng Sun, Ning Hao, Meng Neumann, Helfried Beller, Matthias A general strategy for the synthesis of α-trifluoromethyl- and α-perfluoroalkyl-β-lactams via palladium-catalyzed carbonylation |
title | A general strategy for the synthesis of α-trifluoromethyl- and α-perfluoroalkyl-β-lactams via palladium-catalyzed carbonylation |
title_full | A general strategy for the synthesis of α-trifluoromethyl- and α-perfluoroalkyl-β-lactams via palladium-catalyzed carbonylation |
title_fullStr | A general strategy for the synthesis of α-trifluoromethyl- and α-perfluoroalkyl-β-lactams via palladium-catalyzed carbonylation |
title_full_unstemmed | A general strategy for the synthesis of α-trifluoromethyl- and α-perfluoroalkyl-β-lactams via palladium-catalyzed carbonylation |
title_short | A general strategy for the synthesis of α-trifluoromethyl- and α-perfluoroalkyl-β-lactams via palladium-catalyzed carbonylation |
title_sort | general strategy for the synthesis of α-trifluoromethyl- and α-perfluoroalkyl-β-lactams via palladium-catalyzed carbonylation |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361786/ https://www.ncbi.nlm.nih.gov/pubmed/34447539 http://dx.doi.org/10.1039/d1sc02212a |
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