Lovastatin reduces PEL cell survival by phosphorylating ERK1/2 that blocks the autophagic flux and engages a cross‐talk with p53 to activate p21

Statins are inhibitors of the mevalonate pathway that besides being cholesterol lowering agents, display anti‐cancer properties. This is because cholesterol is an essential component of cell membranes but also because the mevalonate pathway controls protein farnesylation and geranylation, processes...

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Detalles Bibliográficos
Autores principales: Santarelli, Roberta, Pompili, Chiara, Gilardini Montani, Maria Saveria, Romeo, Maria Anele, Gonnella, Roberta, D'Orazi, Gabriella, Cirone, Mara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361952/
https://www.ncbi.nlm.nih.gov/pubmed/33987937
http://dx.doi.org/10.1002/iub.2503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361952/
https://www.ncbi.nlm.nih.gov/pubmed/33987937
http://dx.doi.org/10.1002/iub.2503

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