Genetic Encoding and Enzymatic Deprotection of a Latent Thiol Side Chain to Enable New Protein Bioconjugation Applications

The thiol group of the cysteine side chain is arguably the most versatile chemical handle in proteins. To expand the scope of established and commercially available thiol bioconjugation reagents, we genetically encoded a second such functional moiety in form of a latent thiol group that can be unmas...

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Detalles Bibliográficos
Autores principales: Reille‐Seroussi, Marie, Meyer‐Ahrens, Pascal, Aust, Annika, Feldberg, Anna‐Lena, Mootz, Henning D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361980/
https://www.ncbi.nlm.nih.gov/pubmed/33844389
http://dx.doi.org/10.1002/anie.202102343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361980/
https://www.ncbi.nlm.nih.gov/pubmed/33844389
http://dx.doi.org/10.1002/anie.202102343

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