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On‐demand treatment with the iron chelator deferasirox is ineffective in preventing blood‐induced joint damage in haemophilic mice

INTRODUCTION: Early intervention in the devastating process of haemophilic arthropathy (HA) is highly desirable, but no disease‐modifying therapy is currently available. Considering the pivotal role of iron in the development of HA, iron chelation is considered a promising therapeutic approach. A pr...

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Detalles Bibliográficos
Autores principales: Pulles, Astrid E., van Vulpen, Lize F. D., Coeleveld, Katja, Mastbergen, Simon C., Schutgens, Roger E. G., Lafeber, Floris P. J. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8361985/
https://www.ncbi.nlm.nih.gov/pubmed/34043875
http://dx.doi.org/10.1111/hae.14328