Diethynyl Phosphinates for Cysteine‐Selective Protein Labeling and Disulfide Rebridging

Diethynyl phosphinates were developed as bisfunctional electrophiles for the site‐selective modification of peptides, proteins and antibodies. One of their electron‐deficient triple bonds reacts selectively with a thiol and positions an electrophilic moiety for a subsequent intra‐ or intermolecular...

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Detalles Bibliográficos
Autores principales: Stieger, Christian E., Franz, Luise, Körlin, Frieder, Hackenberger, Christian P. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362001/
https://www.ncbi.nlm.nih.gov/pubmed/34080747
http://dx.doi.org/10.1002/anie.202100683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362001/
https://www.ncbi.nlm.nih.gov/pubmed/34080747
http://dx.doi.org/10.1002/anie.202100683

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