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LEAP‐2/ghrelin interplay in adult growth hormone deficiency: Cause or consequence? A pilot study
Ghrelin and its endogenous antagonist liver‐expressed antimicrobial peptide‐2 (LEAP‐2) are involved in GH secretion and glucose/lipids metabolism. LEAP‐2 expression in conditions of metabolic impairment may be upregulated, usually pairing with a concomitant reduction in ghrelin secretion. Adult grow...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362053/ https://www.ncbi.nlm.nih.gov/pubmed/33991145 http://dx.doi.org/10.1002/iub.2504 |
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author | Vergani, Edoardo Bruno, Carmine Gavotti, Cesare Aversa, Luigi Simone Martire, Maria Mancini, Antonio Currò, Diego |
author_facet | Vergani, Edoardo Bruno, Carmine Gavotti, Cesare Aversa, Luigi Simone Martire, Maria Mancini, Antonio Currò, Diego |
author_sort | Vergani, Edoardo |
collection | PubMed |
description | Ghrelin and its endogenous antagonist liver‐expressed antimicrobial peptide‐2 (LEAP‐2) are involved in GH secretion and glucose/lipids metabolism. LEAP‐2 expression in conditions of metabolic impairment may be upregulated, usually pairing with a concomitant reduction in ghrelin secretion. Adult growth hormone deficiency (aGHD) is characterized by insulin resistance, weight gain, and increased fat mass. Therefore, the primary endpoint of this cross‐sectional observational pilot study was to compare circulating LEAP‐2 and ghrelin levels in aGHD and healthy controls. Thirty patients were included in the study. Group A included adult GHD: 15 patients, 8 females, and 7 males. Median and interquartile range age of the group was 53 (41–57) years, while BMI was 27.1 (25–35) kg/m(2). Group B was formed by 15 healthy controls (10 females and 5 males). Median and interquartile range age was 47 (36–57) years, while BMI 22.9 (20.8–33.1) kg/m(2). They were evaluated for serum glucose and insulin, HOMA‐index, QUICKI‐index, total/LDL/HDL cholesterol, triglycerides, IGF‐1, ghrelin, and LEAP‐2. Ghrelin levels in the aGHD group were significantly lower than in healthy controls. In contrast, LEAP‐2 showed a trend toward higher levels, although the differences were not significant. However, the LEAP‐2/Ghrelin ratio was significantly higher in aGHD. No significant correlations between ghrelin and LEAP‐2 with BMI and HOMA index were found in aGHD population. However, a significant inverse correlation (r (2) = 0.15, p = .047) between BMI and ghrelin was evidenced when considering the whole population. Taken together, these results may suggest a body adaptation to a metabolic scenario typical of aGHD. The decrease in ghrelin production could prevent further weight gain and fat mass increase, although losing its secretagogue effect. |
format | Online Article Text |
id | pubmed-8362053 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83620532021-08-17 LEAP‐2/ghrelin interplay in adult growth hormone deficiency: Cause or consequence? A pilot study Vergani, Edoardo Bruno, Carmine Gavotti, Cesare Aversa, Luigi Simone Martire, Maria Mancini, Antonio Currò, Diego IUBMB Life Research Communications Ghrelin and its endogenous antagonist liver‐expressed antimicrobial peptide‐2 (LEAP‐2) are involved in GH secretion and glucose/lipids metabolism. LEAP‐2 expression in conditions of metabolic impairment may be upregulated, usually pairing with a concomitant reduction in ghrelin secretion. Adult growth hormone deficiency (aGHD) is characterized by insulin resistance, weight gain, and increased fat mass. Therefore, the primary endpoint of this cross‐sectional observational pilot study was to compare circulating LEAP‐2 and ghrelin levels in aGHD and healthy controls. Thirty patients were included in the study. Group A included adult GHD: 15 patients, 8 females, and 7 males. Median and interquartile range age of the group was 53 (41–57) years, while BMI was 27.1 (25–35) kg/m(2). Group B was formed by 15 healthy controls (10 females and 5 males). Median and interquartile range age was 47 (36–57) years, while BMI 22.9 (20.8–33.1) kg/m(2). They were evaluated for serum glucose and insulin, HOMA‐index, QUICKI‐index, total/LDL/HDL cholesterol, triglycerides, IGF‐1, ghrelin, and LEAP‐2. Ghrelin levels in the aGHD group were significantly lower than in healthy controls. In contrast, LEAP‐2 showed a trend toward higher levels, although the differences were not significant. However, the LEAP‐2/Ghrelin ratio was significantly higher in aGHD. No significant correlations between ghrelin and LEAP‐2 with BMI and HOMA index were found in aGHD population. However, a significant inverse correlation (r (2) = 0.15, p = .047) between BMI and ghrelin was evidenced when considering the whole population. Taken together, these results may suggest a body adaptation to a metabolic scenario typical of aGHD. The decrease in ghrelin production could prevent further weight gain and fat mass increase, although losing its secretagogue effect. John Wiley & Sons, Inc. 2021-05-28 2021-07 /pmc/articles/PMC8362053/ /pubmed/33991145 http://dx.doi.org/10.1002/iub.2504 Text en © 2021 The Authors. IUBMB Life published by Wiley Periodicals LLC on behalf of International Union of Biochemistry and Molecular Biology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Communications Vergani, Edoardo Bruno, Carmine Gavotti, Cesare Aversa, Luigi Simone Martire, Maria Mancini, Antonio Currò, Diego LEAP‐2/ghrelin interplay in adult growth hormone deficiency: Cause or consequence? A pilot study |
title | LEAP‐2/ghrelin interplay in adult growth hormone deficiency: Cause or consequence? A pilot study |
title_full | LEAP‐2/ghrelin interplay in adult growth hormone deficiency: Cause or consequence? A pilot study |
title_fullStr | LEAP‐2/ghrelin interplay in adult growth hormone deficiency: Cause or consequence? A pilot study |
title_full_unstemmed | LEAP‐2/ghrelin interplay in adult growth hormone deficiency: Cause or consequence? A pilot study |
title_short | LEAP‐2/ghrelin interplay in adult growth hormone deficiency: Cause or consequence? A pilot study |
title_sort | leap‐2/ghrelin interplay in adult growth hormone deficiency: cause or consequence? a pilot study |
topic | Research Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362053/ https://www.ncbi.nlm.nih.gov/pubmed/33991145 http://dx.doi.org/10.1002/iub.2504 |
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