Proteolysis Targeting Chimera (PROTAC) for Macrophage Migration Inhibitory Factor (MIF) Has Anti‐Proliferative Activity in Lung Cancer Cells

Macrophage migration inhibitory factor (MIF) is involved in protein‐protein interactions that play key roles in inflammation and cancer. Current strategies to develop small molecule modulators of MIF functions are mainly restricted to the MIF tautomerase active site. Here, we use this site to develo...

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Detalles Bibliográficos
Autores principales: Xiao, Zhangping, Song, Shanshan, Chen, Deng, van Merkerk, Ronald, van der Wouden, Petra E., Cool, Robbert H., Quax, Wim J., Poelarends, Gerrit J., Melgert, Barbro N., Dekker, Frank J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362126/
https://www.ncbi.nlm.nih.gov/pubmed/34018657
http://dx.doi.org/10.1002/anie.202101864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362126/
https://www.ncbi.nlm.nih.gov/pubmed/34018657
http://dx.doi.org/10.1002/anie.202101864

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