Acetylenic Replacement of Albicidin's Methacrylamide Residue Circumvents Detrimental E/Z Photoisomerization and Preserves Antibacterial Activity

The natural product albicidin is a highly potent inhibitor of bacterial DNA gyrase. Its outstanding activity, particularly against Gram‐negative pathogens, qualifies it as a promising lead structure in the search for new antibacterial drugs. However, as we show here, the N‐terminal cinnamoyl moiety...

Descripción completa

Detalles Bibliográficos
Autores principales: Behroz, Iraj, Kleebauer, Leonardo, Hommernick, Kay, Seidel, Maria, Grätz, Stefan, Mainz, Andi, Weston, John B., Süssmuth, Roderich D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362182/
https://www.ncbi.nlm.nih.gov/pubmed/33769627
http://dx.doi.org/10.1002/chem.202100523

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362182/
https://www.ncbi.nlm.nih.gov/pubmed/33769627
http://dx.doi.org/10.1002/chem.202100523

Ejemplares similares