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Preclinical Evaluation of the Safety and Efficacy of Cryopreserved Bone Marrow Mesenchymal Stromal Cells for Corneal Repair

PURPOSE: Mesenchymal stromal cells (MSCs) have been shown to enhance tissue repair as a cell-based therapy. In preparation for a phase I clinical study, we evaluated the safety, dosing, and efficacy of bone marrow–derived MSCs after subconjunctival injection in preclinical animal models of mice, rat...

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Detalles Bibliográficos
Autores principales: Putra, Ilham, Shen, Xiang, Anwar, Khandaker N., Rabiee, Behnam, Samaeekia, Ravand, Almazyad, Enmar, Giri, Pushpanjali, Jabbehdari, Sayena, Hayat, Mohammed R., Elhusseiny, Abdelrahman M., Ghassemi, Mahmood, Mahmud, Nadim, Edward, Deepak P., Joslin, Charlotte E., Rosenblatt, Mark I., Dana, Reza, Eslani, Medi, Hematti, Peiman, Djalilian, Ali R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362636/
https://www.ncbi.nlm.nih.gov/pubmed/34383879
http://dx.doi.org/10.1167/tvst.10.10.3