Cargando…

N-acetyl-L-tryptophan attenuates hepatic ischemia-reperfusion injury via regulating TLR4/NLRP3 signaling pathway in rats

The aim of this study was to investigate the changes of TLR4/NLRP3 signal during hepatic ischemia-reperfusion injury (HIRI) and to verify whether N-acetyl-L-tryptophan (L-NAT) protected hepatocytes by regulating the activation of TLR4/NLRP3 signal. We have established the rat HIRI model and H(2)O(2)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pan, Yitong, Yu, Shuna, Wang, Jianxin, Li, Wanzhen, Li, Huiting, Bai, Chen, Sheng, Yaxin, Li, Ming, Wang, Chenchen, Liu, Jiao, Xie, Peitong, Wang, Can, Jiang, Jiying, Li, Jianguo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2021
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362669/ https://www.ncbi.nlm.nih.gov/pubmed/34434653 http://dx.doi.org/10.7717/peerj.11909

Ejemplares similares

Ac2-26 attenuates hepatic ischemia-reperfusion injury in mice via regulating IL-22/IL-22R1/STAT3 signaling
por: Li, Wanzhen, et al.
Publicado: (2022)

Inhibition of excessive mitophagy by N-acetyl-L-tryptophan confers hepatoprotection against Ischemia-Reperfusion injury in rats
por: Li, Huiting, et al.
Publicado: (2020)

Protective role of N-acetyl-l-tryptophan against hepatic ischemia-reperfusion injury via the RIP2/caspase-1/IL-1β signaling pathway
por: Wang, Jianxin, et al.
Publicado: (2019)

Ac2‑26 alleviates hepatic ischemia‑reperfusion injury based on inhibiting the positive feedback loop of HMGB1/TLR4/NF‑κB/neutrophils
por: Bai, Chen, et al.
Publicado: (2022)

Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review
por: Liu, Cuihua, et al.
Publicado: (2023)

Naringenin attenuates inflammation and apoptosis of osteoarthritic chondrocytes via the TLR4/TRAF6/NF-κB pathway
por: Wang, Yan, et al.
Publicado: (2023)

Taxifolin protects rat against myocardial ischemia/reperfusion injury by modulating the mitochondrial apoptosis pathway
por: Tang, Zhenqiu, et al.
Publicado: (2019)

The role of acetyl-coA carboxylase2 in head and neck squamous cell carcinoma
por: Li, Kun, et al.
Publicado: (2019)

Epigenetic modification mechanism of histone demethylase KDM1A in regulating cardiomyocyte apoptosis after myocardial ischemia-reperfusion injury
por: He, Lin, et al.
Publicado: (2022)

Treatment with sodium (S)-2-hydroxyglutarate prevents liver injury in an ischemia-reperfusion model in female Wistar rats
por: Cienfuegos-Pecina, Eduardo, et al.
Publicado: (2021)

Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stress
por: Wang, Jinyang, et al.
Publicado: (2023)

Protein kinase C coordinates histone H3 phosphorylation and acetylation
por: Darieva, Zoulfia, et al.
Publicado: (2015)

TLR4 Enhances Cerebral Ischemia/Reperfusion Injury via Regulating NLRP3 Inflammasome and Autophagy
por: Mao, Li, et al.
Publicado: (2023)

NLRP3 inflammasome activation mediates sleep deprivation-induced pyroptosis in mice
por: Fan, Kun, et al.
Publicado: (2021)

Protective Effect of N-Acetylserotonin against Acute Hepatic Ischemia-Reperfusion Injury in Mice
por: Yu, Shuna, et al.
Publicado: (2013)

Resveratrol improves cardiac function and left ventricular fibrosis after myocardial infarction in rats by inhibiting NLRP3 inflammasome activity and the TGF-β1/SMAD2 signaling pathway
por: Jiang, Jinjin, et al.
Publicado: (2021)

Theacrine alleviates sepsis-induced acute kidney injury by repressing the activation of NLRP3/Caspase-1 inflammasome
por: Yang, Maoxian, et al.
Publicado: (2022)

Breviscapine alleviates podocyte injury by inhibiting NF-κB/NLRP3-mediated pyroptosis in diabetic nephropathy
por: Sun, Linlin, et al.
Publicado: (2023)

m(6)A eraser ALKBH5 mitigates the apoptosis of cardiomyocytes in ischemia reperfusion injury through m(6)A/SIRT1 axis
por: Liu, Liangliang, et al.
Publicado: (2023)

Lipid raft localization of TLR2 and its co-receptors is independent of membrane lipid composition
por: Hellwing, Christine, et al.
Publicado: (2018)

The effect of cartilage decellularized extracellular matrix-chitosan compound on treating knee osteoarthritis in rats
por: Chen, Deng, et al.
Publicado: (2021)

Paeoniflorin improves functional recovery through repressing neuroinflammation and facilitating neurogenesis in rat stroke model
por: Tang, Hongli, et al.
Publicado: (2021)

Altered expression profile of glycolytic enzymes during testicular ischemia reperfusion injury is associated with the p53/TIGAR pathway: effect of fructose 1,6-diphosphate
por: Al-Maghrebi, May, et al.
Publicado: (2016)

Increased chemical acetylation of peptides and proteins in rats after daily ingestion of diacetyl analyzed by Nano-LC-MS/MS
por: Jedlicka, Leticia Dias Lima, et al.
Publicado: (2018)

Effect of sodium (S)-2-hydroxyglutarate in male, and succinic acid in female Wistar rats against renal ischemia-reperfusion injury, suggesting a role of the HIF-1 pathway
por: Cienfuegos-Pecina, Eduardo, et al.
Publicado: (2020)

LPS- or Pseudomonas aeruginosa-mediated activation of the macrophage TLR4 signaling cascade depends on membrane lipid composition
por: Schoeniger, Axel, et al.
Publicado: (2016)

Acetylation of N-terminus and two internal amino acids is dispensable for degradation of a protein that aberrantly engages the endoplasmic reticulum translocon
por: Engle, Sarah M., et al.
Publicado: (2017)

Detection of methylation, acetylation and glycosylation of protein residues by monitoring (13)C chemical-shift changes: A quantum-chemical study
por: Garay, Pablo G., et al.
Publicado: (2016)

Differential expression of lysine acetylation proteins in gastric cancer treated with a new antitumor agent bioactive peptide chelate selenium
por: Xu, Yanan, et al.
Publicado: (2023)

RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity
por: McKelvey, Alison C, et al.
Publicado: (2016)

Effects of substituting soybean meal with corn on immune function and gene expression of gut TLR4 pathway of growing goats
por: Cheng, Yan, et al.
Publicado: (2022)

Progress in the mechanism of autophagy and traditional Chinese medicine herb involved in alcohol-related liver disease
por: Han, Wenwen, et al.
Publicado: (2023)

MicroRNA let-7f-5p regulates PI3K/AKT/COX2 signaling pathway in bacteria-induced pulmonary fibrosis via targeting of PIK3CA in forest musk deer
por: Zhao, Wei, et al.
Publicado: (2022)

UHPLC-ESI-QE-Orbitrap-MS based metabolomics reveals the antioxidant mechanism of icaritin on mice with cerebral ischemic reperfusion
por: Tang, Yunfeng, et al.
Publicado: (2023)

Cardioprotective effects of Prolame and SNAP are related with nitric oxide production and with diminution of caspases and calpain-1 activities in reperfused rat hearts
por: Román-Anguiano, Nadia Giovanna, et al.
Publicado: (2019)

Biochanin A attenuates myocardial ischemia/reperfusion injury through the TLR4/NF-κB/NLRP3 signaling pathway
por: Bai, Yejun, et al.
Publicado: (2019)

LncRNA OIP5-AS1 modulates the proliferation and apoptosis of Jurkat cells by sponging miR-181c-5p to regulate IL-7 expression in myasthenia gravis
por: Wang, Xu, et al.
Publicado: (2022)

The regulation of immune checkpoints by the hypoxic tumor microenvironment
por: Hu, Min, et al.
Publicado: (2021)

Transcription factor organic cation transporter 1 (OCT-1) affects the expression of porcine Klotho (KL) gene
por: Li, Yan, et al.
Publicado: (2016)

Mild Hypothermia Therapy Lowers the Inflammatory Level and Apoptosis Rate of Myocardial Cells of Rats with Myocardial Ischemia-Reperfusion Injury via the NLRP3 Inflammasome Pathway
por: Gao, Renjun, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ubukcapf130uhqsafm13ck205c