SPOP and CUL3 Modulate the Sonic Hedgehog Signal Response Through Controlled Degradation of GLI Family Transcription Factors

The speckle-type POZ protein (SPOP) functions as a guardian of genome integrity and controls transcriptional regulation by functioning as a substrate adaptor for CUL3/RING-type E3 ubiquitin ligase complexes. SPOP-containing CUL3 complexes target a myriad of DNA-binding proteins involved in DNA repai...

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Detalles Bibliográficos
Autores principales: Umberger, Patricia A., Ogden, Stacey K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362800/
https://www.ncbi.nlm.nih.gov/pubmed/34395437
http://dx.doi.org/10.3389/fcell.2021.710295

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362800/
https://www.ncbi.nlm.nih.gov/pubmed/34395437
http://dx.doi.org/10.3389/fcell.2021.710295

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