An Autism-Associated de novo Mutation in GluN2B Destabilizes Growing Dendrites by Promoting Retraction and Pruning

Mutations in GRIN2B, which encodes the GluN2B subunit of NMDA receptors, lead to autism spectrum disorders (ASD), but the pathophysiological mechanisms remain unclear. Recently, we showed that a GluN2B variant that is associated with severe ASD (GluN2B(724t)) impairs dendrite morphogenesis. To deter...

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Detalles Bibliográficos
Autores principales: Bahry, Jacob A., Fedder-Semmes, Karlie N., Sceniak, Michael P., Sabo, Shasta L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363002/
https://www.ncbi.nlm.nih.gov/pubmed/34393725
http://dx.doi.org/10.3389/fncel.2021.692232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363002/
https://www.ncbi.nlm.nih.gov/pubmed/34393725
http://dx.doi.org/10.3389/fncel.2021.692232

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