Calcineurin Activation by Prion Protein Induces Neurotoxicity via Mitochondrial Reactive Oxygen Species

Prion diseases are caused by PrPsc accumulation in the brain, which triggers dysfunctional mitochondrial injury and reactive oxygen species (ROS) generation in neurons. Recent studies on prion diseases suggest that endoplasmic reticulum (ER) stress induced by misfolding proteins such as misfolded pr...

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Detalles Bibliográficos
Autores principales: Moon, Ji-Hong, Hong, Jeong-Min, Park, Sang-Youel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363446/
https://www.ncbi.nlm.nih.gov/pubmed/34394828
http://dx.doi.org/10.1155/2021/5572129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363446/
https://www.ncbi.nlm.nih.gov/pubmed/34394828
http://dx.doi.org/10.1155/2021/5572129

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