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An Alternative Data Transformation Approach for ADA Cut Point Determination: Why Not Use a Weibull Transformation?

The testing of protein drug candidates for inducing the generation of anti-drug antibodies (ADA) plays a fundamental role in drug development. The basis of the testing strategy includes a screening assay followed by a confirmatory test. Screening assay cut points (CP) are calculated mainly based on...

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Detalles Bibliográficos
Autores principales: Jordan, Gregor, Staack, Roland F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363525/
https://www.ncbi.nlm.nih.gov/pubmed/34389881
http://dx.doi.org/10.1208/s12248-021-00625-6