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An Alternative Data Transformation Approach for ADA Cut Point Determination: Why Not Use a Weibull Transformation?
The testing of protein drug candidates for inducing the generation of anti-drug antibodies (ADA) plays a fundamental role in drug development. The basis of the testing strategy includes a screening assay followed by a confirmatory test. Screening assay cut points (CP) are calculated mainly based on...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer International Publishing
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363525/ https://www.ncbi.nlm.nih.gov/pubmed/34389881 http://dx.doi.org/10.1208/s12248-021-00625-6 |