The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis

Diabetes results from a decline in functional pancreatic β-cells, but the molecular mechanisms underlying the pathological β-cell failure are poorly understood. Here we report that large-tumor suppressor 2 (LATS2), a core component of the Hippo signaling pathway, is activated under diabetic conditio...

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Detalles Bibliográficos
Autores principales: Yuan, Ting, Annamalai, Karthika, Naik, Shruti, Lupse, Blaz, Geravandi, Shirin, Pal, Anasua, Dobrowolski, Aleksandra, Ghawali, Jaee, Ruhlandt, Marina, Gorrepati, Kanaka Durga Devi, Azizi, Zahra, Lim, Dae-Sik, Maedler, Kathrin, Ardestani, Amin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363615/
https://www.ncbi.nlm.nih.gov/pubmed/34389720
http://dx.doi.org/10.1038/s41467-021-25145-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363615/
https://www.ncbi.nlm.nih.gov/pubmed/34389720
http://dx.doi.org/10.1038/s41467-021-25145-x

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