Nucleolar release of rDNA repeats for repair involves SUMO-mediated untethering by the Cdc48/p97 segregase

Ribosomal RNA genes (rDNA) are highly unstable and susceptible to rearrangement due to their repetitive nature and active transcriptional status. Sequestration of rDNA in the nucleolus suppresses uncontrolled recombination. However, broken repeats must be first released to the nucleoplasm to allow r...

Descripción completa

Detalles Bibliográficos
Autores principales: Capella, Matías, Mandemaker, Imke K., Martín Caballero, Lucía, den Brave, Fabian, Pfander, Boris, Ladurner, Andreas G., Jentsch, Stefan, Braun, Sigurd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363623/
https://www.ncbi.nlm.nih.gov/pubmed/34389719
http://dx.doi.org/10.1038/s41467-021-25205-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363623/
https://www.ncbi.nlm.nih.gov/pubmed/34389719
http://dx.doi.org/10.1038/s41467-021-25205-2

Ejemplares similares