Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD

C9ORF72 hexanucleotide GGGGCC repeat expansion is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Repeat-containing RNA mediates toxicity through nuclear granules and dipeptide repeat (DPR) proteins produced by repeat-associated non-AUG transla...

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Detalles Bibliográficos
Autores principales: Wang, Shaopeng, Latallo, Malgorzata J., Zhang, Zhe, Huang, Bo, Bobrovnikov, Dmitriy G., Dong, Daoyuan, Livingston, Nathan M., Tjoeng, Wilson, Hayes, Lindsey R., Rothstein, Jeffrey D., Ostrow, Lyle W., Wu, Bin, Sun, Shuying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363653/
https://www.ncbi.nlm.nih.gov/pubmed/34389711
http://dx.doi.org/10.1038/s41467-021-25082-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363653/
https://www.ncbi.nlm.nih.gov/pubmed/34389711
http://dx.doi.org/10.1038/s41467-021-25082-9

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