A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells

BRCA1 or BRCA2 germline mutations predispose to breast, ovarian and other cancers. High-throughput sequencing of tumour genomes revealed that oncogene amplification and BRCA1/2 mutations are mutually exclusive in cancer, however the molecular mechanism underlying this incompatibility remains unknown...

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Detalles Bibliográficos
Autores principales: Dagg, Rebecca A., Zonderland, Gijs, Lombardi, Emilia Puig, Rossetti, Giacomo G., Groelly, Florian J., Barroso, Sonia, Tacconi, Eliana M. C., Wright, Benjamin, Lockstone, Helen, Aguilera, Andrés, Halazonetis, Thanos D., Tarsounas, Madalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363664/
https://www.ncbi.nlm.nih.gov/pubmed/34389725
http://dx.doi.org/10.1038/s41467-021-25215-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363664/
https://www.ncbi.nlm.nih.gov/pubmed/34389725
http://dx.doi.org/10.1038/s41467-021-25215-0

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