Cargando…

PD-L1(+) and XCR1(+) dendritic cells are region-specific regulators of gut homeostasis

The intestinal mucosa constitutes an environment of closely regulated immune cells. Dendritic cells (DC) interact with the gut microbiome and antigens and are important in maintaining gut homeostasis. Here, we investigate DC transcriptome, phenotype and function in five anatomical locations of the g...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moreira, Thais G., Mangani, Davide, Cox, Laura M., Leibowitz, Jeffrey, Lobo, Eduardo. L. C., Oliveira, Mariana A., Gauthier, Christian D., Nakagaki, Brenda N., Willocq, Valerie, Song, Anya, Guo, Lydia, Lima, David C. A., Murugaiyan, Gopal, Butovsky, Oleg, Gabriely, Galina, Anderson, Ana C., Rezende, Rafael M., Faria, Ana Maria C., Weiner, Howard L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363668/ https://www.ncbi.nlm.nih.gov/pubmed/34389726 http://dx.doi.org/10.1038/s41467-021-25115-3

Ejemplares similares

Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis
por: Ohta, Tomokazu, et al.
Publicado: (2016)

Development and function of chicken XCR1(+) conventional dendritic cells
por: Wu, Zhiguang, et al.
Publicado: (2023)

Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity
por: Garo, Lucien P., et al.
Publicado: (2019)

The role of the chemokine receptor XCR1 in breast cancer cells
por: Yang, Xiao Li, et al.
Publicado: (2017)

Ontogenic, Phenotypic, and Functional Characterization of XCR1(+) Dendritic Cells Leads to a Consistent Classification of Intestinal Dendritic Cells Based on the Expression of XCR1 and SIRPα
por: Becker, Martina, et al.
Publicado: (2014)

Cross-Presenting XCR1(+) Dendritic Cells as Targets for Cancer Immunotherapy
por: Audsley, Katherine M., et al.
Publicado: (2020)

Structure-Function Relationship of XCL1 Used for in vivo Targeting of Antigen Into XCR1(+) Dendritic Cells
por: Kroczek, Arthur L., et al.
Publicado: (2018)

Harnessing Human Cross-Presenting CLEC9A(+)XCR1(+) Dendritic Cells for Immunotherapy
por: Tullett, Kirsteen M., et al.
Publicado: (2014)

Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males
por: Abou-El-Hassan, Hadi, et al.
Publicado: (2023)

The Role of XCR1 and its Ligand XCL1 in Antigen Cross-Presentation by Murine and Human Dendritic Cells
por: Kroczek, Richard A., et al.
Publicado: (2012)

Myeloid cell subsets that express latency-associated peptide promote cancer growth by modulating T cells
por: Gabriely, Galina, et al.
Publicado: (2021)

The anti-influenza M2e antibody response is promoted by XCR1 targeting in pig skin
por: Deloizy, Charlotte, et al.
Publicado: (2017)

Traumatic brain injury in mice induces changes in the expression of the XCL1/XCR1 and XCL1/ITGA9 axes
por: Ciechanowska, Agata, et al.
Publicado: (2020)

Expression of XCR1 Characterizes the Batf3-Dependent Lineage of Dendritic Cells Capable of Antigen Cross-Presentation
por: Bachem, Annabell, et al.
Publicado: (2012)

Tolerogenic XCR1(+) dendritic cell population is dysregulated in HLA-B27 transgenic rat model of spondyloarthritis
por: Ermoza, Kétia, et al.
Publicado: (2019)

Novel Targeting to XCR1(+) Dendritic Cells Using Allogeneic T Cells for Polytopical Antibody Responses in the Lymph Nodes
por: Kitazawa, Yusuke, et al.
Publicado: (2019)

XCR1 expression distinguishes human conventional dendritic cell type 1 with full effector functions from their immediate precursors
por: Heger, Lukas, et al.
Publicado: (2023)

The microbiota restrains neurodegenerative microglia in a model of amyotrophic lateral sclerosis
por: Cox, Laura M., et al.
Publicado: (2022)

Mouse Conventional Dendritic Cells Can be Universally Classified Based on the Mutually Exclusive Expression of XCR1 and SIRPα
por: Gurka, Stephanie, et al.
Publicado: (2015)

Targeting Xcr1 on Dendritic Cells Rapidly Induce Th1-Associated Immune Responses That Contribute to Protection Against Influenza Infection
por: Tesfaye, Demo Yemane, et al.
Publicado: (2022)

CD8(+)XCR1(neg) Dendritic Cells Express High Levels of Toll-Like Receptor 5 and a Unique Complement of Endocytic Receptors
por: Wylie, Ben, et al.
Publicado: (2019)

Therapeutically targeting type I interferon directly to XCR1+ dendritic cells reveals the role of cDC1s in anti-drug antibodies
por: Noe, Paul, et al.
Publicado: (2023)

MicroRNA-21, T helper lineage and autoimmunity
por: Murugaiyan, Gopal, et al.
Publicado: (2015)

MicroRNA-146a limits tumorigenic inflammation in colorectal cancer
por: Garo, Lucien P., et al.
Publicado: (2021)

The Identification and Distribution of Cattle XCR1 and XCL1 among Peripheral Blood Cells: New Insights into the Design of Dendritic Cells Targeted Veterinary Vaccine
por: Li, Kun, et al.
Publicado: (2017)

XCR1(+) dendritic cells promote memory CD8(+) T cell recall upon secondary infections with Listeria monocytogenes or certain viruses
por: Alexandre, Yannick O., et al.
Publicado: (2016)

Development of novel reagents to chicken FLT3, XCR1 and CSF2R for the identification and characterization of avian conventional dendritic cells
por: Wu, Zhiguang, et al.
Publicado: (2021)

Nasal administration of anti-CD3 mAb (Foralumab) downregulates NKG7 and increases TGFB1 and GIMAP7 expression in T cells in subjects with COVID-19
por: G. Moreira, Thais, et al.
Publicado: (2023)

A Novel Role for Lymphotactin (XCL1) Signaling in the Nervous System: XCL1 Acts via its Receptor XCR1 to Increase Trigeminal Neuronal Excitability
por: Bird, Emma V., et al.
Publicado: (2018)

Gamma-delta T cells modulate the microbiota and fecal micro-RNAs to maintain mucosal tolerance
por: Rezende, Rafael M., et al.
Publicado: (2023)

γδ T cells control humoral immune response by inducing T follicular helper cell differentiation
por: Rezende, Rafael M., et al.
Publicado: (2018)

microRNA-92a promotes CNS autoimmunity by modulating the regulatory and inflammatory T cell balance
por: Fujiwara, Mai, et al.
Publicado: (2022)

IL-27p28 Production by XCR1(+) Dendritic Cells and Monocytes Effectively Predicts Adjuvant-Elicited CD8(+) T Cell Responses
por: Kilgore, Augustus M., et al.
Publicado: (2018)

New insights into the analgesic properties of the XCL1/XCR1 and XCL1/ITGA9 axes modulation under neuropathic pain conditions - evidence from animal studies
por: Ciechanowska, Agata, et al.
Publicado: (2022)

Identification and characterization of latency-associated peptide-expressing γδ T cells
por: Rezende, Rafael M., et al.
Publicado: (2015)

Construction of a 13-Gene Signature as a Novel Prognostic Marker for Patients with Clear Cell Renal Cell Carcinoma and the Role of XCR1 in Cell Proliferation
por: Yuan, Baoying, et al.
Publicado: (2020)

TIM-3 blockade enhances IL-12-dependent antitumor immunity by promoting CD8(+) T cell and XCR1(+) dendritic cell spatial co-localization
por: Gardner, Alycia, et al.
Publicado: (2022)

Langerin-expressing dendritic cells in human tissues are related to CD1c(+) dendritic cells and distinct from Langerhans cells and CD141(high) XCR1(+) dendritic cells
por: Bigley, Venetia, et al.
Publicado: (2015)

Loss of ‘homeostatic’ microglia and patterns of their activation in active multiple sclerosis
por: Zrzavy, Tobias, et al.
Publicado: (2017)

Superior antigen cross-presentation and XCR1 expression define human CD11c(+)CD141(+) cells as homologues of mouse CD8(+) dendritic cells
por: Bachem, Annabell, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_i3q583lous9v8rraa63mn9db1l