Safety and Pharmacokinetics of HTL0018318, a Novel M(1) Receptor Agonist, Given in Combination with Donepezil at Steady State: A Randomized Trial in Healthy Elderly Subjects

INTRODUCTION: HTL0018318 is a selective muscarinic M(1) receptor partial agonist under development for the symptomatic treatment of dementias, including Alzheimer’s disease. Clinically, HTL0018318 would likely be used alone or in conjunction with cholinesterase inhibitors (e.g. donepezil). OBJECTIVE...

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Detalles Bibliográficos
Autores principales: Bakker, Charlotte, van der Aart, Jasper, Labots, Geert, Liptrot, Jan, Cross, David M., Klaassen, Erica S., Dickinson, Steve, Tasker, Tim, Groeneveld, Geert Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363684/
https://www.ncbi.nlm.nih.gov/pubmed/34164794
http://dx.doi.org/10.1007/s40268-021-00352-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363684/
https://www.ncbi.nlm.nih.gov/pubmed/34164794
http://dx.doi.org/10.1007/s40268-021-00352-5

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