Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging blood

Age-related clonal hematopoiesis (ARCH) is characterized by age-associated accumulation of somatic mutations in hematopoietic stem cells (HSCs) or their pluripotent descendants. HSCs harboring driver mutations will be positively selected and cells carrying these mutations will rise in frequency. Whi...

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Detalles Bibliográficos
Autores principales: Skead, Kimberly, Ang Houle, Armande, Abelson, Sagi, Agbessi, Mawusse, Bruat, Vanessa, Lin, Boxi, Soave, David, Shlush, Liran, Wright, Stephen, Dick, John, Morris, Quaid, Awadalla, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363714/
https://www.ncbi.nlm.nih.gov/pubmed/34389724
http://dx.doi.org/10.1038/s41467-021-25172-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363714/
https://www.ncbi.nlm.nih.gov/pubmed/34389724
http://dx.doi.org/10.1038/s41467-021-25172-8

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