Hyperleptinemia in obese state renders luminal breast cancers refractory to tamoxifen by coordinating a crosstalk between Med1, miR205 and ErbB

Obese women with hormone receptor-positive breast cancer exhibit poor response to therapy and inferior outcomes. However, the underlying molecular mechanisms by which obesity/hyperleptinemia may reduce the efficacy of hormonal therapy remain elusive. Obese mice with hyperleptinemia exhibit increased...

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Detalles Bibliográficos
Autores principales: Nagalingam, Arumugam, Siddharth, Sumit, Parida, Sheetal, Muniraj, Nethaji, Avtanski, Dimiter, Kuppusamy, Panjamurthy, Elsey, Justin, Arbiser, Jack L., Győrffy, Balázs, Sharma, Dipali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363746/
https://www.ncbi.nlm.nih.gov/pubmed/34389732
http://dx.doi.org/10.1038/s41523-021-00314-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363746/
https://www.ncbi.nlm.nih.gov/pubmed/34389732
http://dx.doi.org/10.1038/s41523-021-00314-9

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