Evidence for long-term association of virion-delivered HBV core protein with cccDNA independently of viral protein production

BACKGROUND & AIMS: HBV persists in the nucleus of infected hepatocytes as a covalently closed circular DNA (cccDNA) episome that constitutes the template for viral RNA and protein synthesis. Both HBx and HBc (core) viral proteins associate with cccDNA but, while HBx is required for viral transcr...

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Detalles Bibliográficos
Autores principales: Lucifora, Julie, Pastor, Florentin, Charles, Émilie, Pons, Caroline, Auclair, Héloïse, Fusil, Floriane, Rivoire, Michel, Cosset, François-Loïc, Durantel, David, Salvetti, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363821/
https://www.ncbi.nlm.nih.gov/pubmed/34409278
http://dx.doi.org/10.1016/j.jhepr.2021.100330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363821/
https://www.ncbi.nlm.nih.gov/pubmed/34409278
http://dx.doi.org/10.1016/j.jhepr.2021.100330

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