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Heparin promotes fibrillation of most phenol-soluble modulin virulence peptides from Staphylococcus aureus

Phenol-soluble modulins (PSMs), such as α-PSMs, β-PSMs, and δ-toxin, are virulence peptides secreted by different Staphylococcus aureus strains. PSMs are able to form amyloid fibrils, which may strengthen the biofilm matrix that promotes bacterial colonization of and extended growth on surfaces (e.g...

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Detalles Bibliográficos
Autores principales: Najarzadeh, Zahra, Zaman, Masihuz, Sereikaite, Vita, Strømgaard, Kristian, Andreasen, Maria, Otzen, Daniel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363829/
https://www.ncbi.nlm.nih.gov/pubmed/34270957
http://dx.doi.org/10.1016/j.jbc.2021.100953