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Defective insulin-stimulated GLUT4 translocation in brown adipocytes induces systemic glucose homeostasis dysregulation independent of thermogenesis in female mice
OBJECTIVE: Recent studies indicate that brown adipose tissue, in addition to its role in thermogenesis, has a role in the regulation of whole-body metabolism. Here we characterize the metabolic effects of deleting Rab10, a protein key for insulin stimulation of glucose uptake into white adipocytes,...
Autores principales: | Picatoste, Belén, Yammine, Lucie, Leahey, Rosemary A., Soares, David, Johnson, Emma F., Cohen, Paul, McGraw, Timothy E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363886/ https://www.ncbi.nlm.nih.gov/pubmed/34303022 http://dx.doi.org/10.1016/j.molmet.2021.101305 |
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