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Deep learning based mixed-dimensional GMM for characterizing variability in CryoEM

Structural flexibility and/or dynamic interactions with other molecules is a critical aspect of protein function. CryoEM provides direct visualization of individual macromolecules sampling different conformational and compositional states. While numerous methods are available for computational class...

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Detalles Bibliográficos
Autores principales: Chen, Muyuan, Ludtke, Steven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363932/
https://www.ncbi.nlm.nih.gov/pubmed/34326541
http://dx.doi.org/10.1038/s41592-021-01220-5