Generation of human embryonic stem cell models to exploit the EWSR1-CREB fusion promiscuity as a common pathway of transformation in human tumors

Chromosomal translocations constitute driver mutations in solid tumors and leukemias. The mechanisms of how related or even identical gene fusions drive the pathogenesis of various tumor types remain elusive. One remarkable example is the presence of EWSR1 fusions with CREB1 and ATF1, members of the...

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Detalles Bibliográficos
Autores principales: Vanoli, Fabio, Meskauskaite, Brigita, Herviou, Laurie, Mallen, William, Sung, Yun-Shao, Fujisawa, Yumi, Zhang, Lei, Simon, Steven, Huangfu, Danwei, Jasin, Maria, Antonescu, Cristina R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364490/
https://www.ncbi.nlm.nih.gov/pubmed/34193943
http://dx.doi.org/10.1038/s41388-021-01843-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364490/
https://www.ncbi.nlm.nih.gov/pubmed/34193943
http://dx.doi.org/10.1038/s41388-021-01843-0

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