Direct phosphorylation and stabilization of HIF-1α by PIM1 kinase drives angiogenesis in solid tumors

Angiogenesis is essential for the sustained growth of solid tumors. Hypoxia-inducible factor 1 (HIF-1) is a master regulator of angiogenesis and constitutive activation of HIF-1 is frequently observed in human cancers. Therefore, understanding the mechanisms governing the activation of HIF-1 is crit...

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Detalles Bibliográficos
Autores principales: Casillas, Andrea L., Chauhan, Shailender S., Toth, Rachel K., Sainz, Alva G., Clements, Amber N., Jensen, Corbin C., Langlais, Paul R., Miranti, Cindy K., Cress, Anne E., Warfel, Noel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364516/
https://www.ncbi.nlm.nih.gov/pubmed/34211090
http://dx.doi.org/10.1038/s41388-021-01915-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364516/
https://www.ncbi.nlm.nih.gov/pubmed/34211090
http://dx.doi.org/10.1038/s41388-021-01915-1

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