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Direct phosphorylation and stabilization of HIF-1α by PIM1 kinase drives angiogenesis in solid tumors

Angiogenesis is essential for the sustained growth of solid tumors. Hypoxia-inducible factor 1 (HIF-1) is a master regulator of angiogenesis and constitutive activation of HIF-1 is frequently observed in human cancers. Therefore, understanding the mechanisms governing the activation of HIF-1 is crit...

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Detalles Bibliográficos
Autores principales:	Casillas, Andrea L., Chauhan, Shailender S., Toth, Rachel K., Sainz, Alva G., Clements, Amber N., Jensen, Corbin C., Langlais, Paul R., Miranti, Cindy K., Cress, Anne E., Warfel, Noel A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364516/ https://www.ncbi.nlm.nih.gov/pubmed/34211090 http://dx.doi.org/10.1038/s41388-021-01915-1

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