Cargando…

A model for COVID-19-induced dysregulation of ACE2 shedding by ADAM17

The angiotensin Converting Enzyme 2 (ACE2) receptor is a key component of the renin-angiotensin-aldesterone system (RAAS) that mediates numerous effects in the cardiovascular system. It is also the cellular point of contact for the coronavirus spike protein. Cleavage of the receptor is both importan...

Descripción completa

Detalles Bibliográficos
Autores principales:	Healy, Eamonn F., Lilic, Marko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364680/ https://www.ncbi.nlm.nih.gov/pubmed/34416436 http://dx.doi.org/10.1016/j.bbrc.2021.08.040

Ejemplares similares

How tetraspanin-mediated cell entry of SARS-CoV-2 can dysregulate the shedding of the ACE2 receptor by ADAM17
por: Healy, Eamonn F.
Publicado: (2022)

The collectrin‐like part of the SARS‐CoV‐1 and ‐2 receptor ACE2 is shed by the metalloproteinases ADAM10 and ADAM17
por: Niehues, Rabea Victoria, et al.
Publicado: (2022)

ADAM17 knockdown mitigates while ADAM17 overexpression aggravates cardiac fibrosis and dysfunction via regulating ACE2 shedding and myofibroblast transformation
por: Cheng, Jing, et al.
Publicado: (2022)

Activation of Kinin B1R Upregulates ADAM17 and Results in ACE2 Shedding in Neurons
por: Parekh, Rohan Umesh, et al.
Publicado: (2020)

Dynamics of ADAM17-Mediated Shedding of ACE2 Applied to Pancreatic Islets of Male db/db Mice
por: Pedersen, Kim Brint, et al.
Publicado: (2015)

Lung ACE2 and ADAM17 in pulmonary arterial hypertension: Implications for COVID-19?
por: Pérez-Vizcaíno, Francisco
Publicado: (2020)

LRP1 shedding in human brain: roles of ADAM10 and ADAM17
por: Liu, Qiang, et al.
Publicado: (2009)

miR-145 Alleviates Smooth Muscle Cell Phenotype Transition via ADAM17-Mediated ACE2 Shedding
por: Wen, Juan, et al.
Publicado: (2023)

ADAM17-Mediated Shedding of Inflammatory Cytokines in Hypertension
por: de Queiroz, Thyago M., et al.
Publicado: (2020)

Involvement of shedding induced by ADAM17 on the nitric oxide pathway in hypertension
por: da Silva, Mirelly Cunha, et al.
Publicado: (2022)

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
por: Sahin, Umut, et al.
Publicado: (2004)

ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19
por: Zipeto, Donato, et al.
Publicado: (2020)

ADAM10 mediates shedding of carbonic anhydrase IX ectodomain non-redundantly to ADAM17
por: Zatovicova, Miriam, et al.
Publicado: (2022)

ACE2 Shedding and the Role in COVID-19
por: Wang, Jieqiong, et al.
Publicado: (2022)

P38 MAPK activated ADAM17 mediates ACE2 shedding and promotes cardiac remodeling and heart failure after myocardial infarction
por: Chen, Qi, et al.
Publicado: (2023)

ADAM17 is essential for ectodomain shedding of the EGF‐receptor ligand amphiregulin
por: Hosur, Vishnu, et al.
Publicado: (2018)

Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE
por: Cavadas, Miguel, et al.
Publicado: (2017)

Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP
por: Sammel, Martin, et al.
Publicado: (2019)

Estrogen receptors are linked to angiotensin-converting enzyme 2 (ACE2), ADAM metallopeptidase domain 17 (ADAM-17), and transmembrane protease serine 2 (TMPRSS2) expression in the human atrium: insights into COVID-19
por: Wang, Hao, et al.
Publicado: (2021)

Tetraspanin CD9 modulates ADAM17-mediated shedding of LR11 in leukocytes
por: Tsukamoto, Shokichi, et al.
Publicado: (2014)

ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium
por: Ma, Xiang, et al.
Publicado: (2021)

Ectodomain shedding of the hypoxia-induced carbonic anhydrase IX is a metalloprotease-dependent process regulated by TACE/ADAM17
por: Zatovicova, M, et al.
Publicado: (2005)

Ectodomain Shedding by ADAM17: Its Role in Neutrophil Recruitment and the Impairment of This Process during Sepsis
por: Mishra, Hemant K., et al.
Publicado: (2017)

ADAM17-mediated EGFR ligand shedding directs macrophage-promoted cancer cell invasion
por: Gnosa, Sebastian P., et al.
Publicado: (2022)

Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID‐19 disease
por: Khoury, Emad E., et al.
Publicado: (2021)

Tumor Necrosis Factor-α Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2)
por: Lambert, Daniel W., et al.
Publicado: (2005)

ADAM 17 endopeptidase
Publicado: (2009)

The ADAM15 ectodomain is shed from secretory exosomes
por: Lee, Hee Doo, et al.
Publicado: (2015)

Regulation of ectodomain shedding of ADAM33 in vitro and in vivo
por: Davies, Elizabeth R., et al.
Publicado: (2019)

Effect of 17β-estradiol on the daily pattern of ACE2, ADAM17, TMPRSS2 and estradiol receptor transcription in the lungs and colon of male rats
por: Herichová, Iveta, et al.
Publicado: (2022)

ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis?
por: Maas, Sanne L., et al.
Publicado: (2023)

ADAM10 and ADAM17: New Players in Trastuzumab Resistance
por: Duffy, Michael J., et al.
Publicado: (2014)

ADAM10 and ADAM17—Novel Players in Retinoblastoma Carcinogenesis
por: Van Meenen, Dario, et al.
Publicado: (2022)

Role of ADAMs in the Ectodomain Shedding and Conformational Conversion of the Prion Protein
por: Taylor, David R., et al.
Publicado: (2009)

Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells
por: Cabron, Anne-Sophie, et al.
Publicado: (2018)

The role of S100B/RAGE-enhanced ADAM17 activation in endothelial glycocalyx shedding after traumatic brain injury
por: Zou, Zhimin, et al.
Publicado: (2022)

Diminazen Aceturate Protects Pulmonary Ischemia-Reperfusion Injury via Inhibition of ADAM17-Mediated Angiotensin-Converting Enzyme 2 Shedding
por: Wang, Li-Fang, et al.
Publicado: (2021)

Calcium Signaling Pathway Is Involved in the Shedding of ACE2 Catalytic Ectodomain: New Insights for Clinical and Therapeutic Applications of ACE2 for COVID-19
por: García-Escobar, Artemio, et al.
Publicado: (2022)

NKG2D Ligand Shedding in Response to Stress: Role of ADAM10
por: Zingoni, Alessandra, et al.
Publicado: (2020)

Extracellular sphingomyelinase activity impairs TNF-α-induced endothelial cell death via ADAM17 activation and TNF receptor 1 shedding
por: Sommer, Anselm, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_8teeuvqsn50chjjhfstlptvq6d