Dysregulated ECM remodeling proteins lead to aberrant osteogenesis of Costello syndrome iPSCs

Costello syndrome (CS) is an autosomal dominant disorder caused by mutations in HRAS. Although CS patients have skeletal abnormalities, the role of mutated HRAS in bone development remains unclear. Here, we use CS induced pluripotent stem cells (iPSCs) undergoing osteogenic differentiation to invest...

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Detalles Bibliográficos
Autores principales: Choi, Jong Bin, Lee, Joonsun, Kang, Minyong, Kim, Bumsoo, Ju, Younghee, Do, Hyo-Sang, Yoo, Han-Wook, Lee, Beom Hee, Han, Yong-Mahn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365028/
https://www.ncbi.nlm.nih.gov/pubmed/34242618
http://dx.doi.org/10.1016/j.stemcr.2021.06.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365028/
https://www.ncbi.nlm.nih.gov/pubmed/34242618
http://dx.doi.org/10.1016/j.stemcr.2021.06.007

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